| 02 |  Zach CharbonnetRB1 · SEA | 179 | 730 rush · 12 TD | 16 | 3.1 | 19.5 | ▲3.2 | | T2 |
| 03 |  Jahmyr GibbsRB2 · DET | 171 | 620 rush · 9 TD | 6 | 17.3 | 41.4 | ▼1.0 | | T2 |
| 08 |  Kenneth Walker IIIRB3 · KC | 148 | 701 rush · 8 TD | 6 | 9.7 | 34.1 | ▼1.9 | | T4 |
| 09 |  Bijan RobinsonRB4 · ATL | 146 | 704 rush · 5 TD | 7 | 7.3 | 35.3 | ▼0.2 | | T4 |
| 11 |  Christian McCaffreyRB5 · SF | 144 | 389 rush · 8 TD | 7 | 13.8 | 30.7 | ▲0.9 | | T4 |
| 13 |  Jonathan TaylorRB6 · IND | 138 | 587 rush · 8 TD | 7 | 9.2 | 29.2 | ▼3.0 | | T4 |
| 16 |  Kyren WilliamsRB7 · LAR | 137 | 492 rush · 6 TD | 7 | 9.7 | 36.7 | ▲1.6 | | T4 |
| 20 |  Javonte WilliamsRB8 · DAL | 131 | 472 rush · 9 TD | 7 | 8 | 31.3 | ▲1.0 | | T5 |
| 28 |  D'Andre SwiftRB9 · CHI | 123 | 476 rush · 7 TD | 7 | 7.4 | 32.4 | ▼2.0 | | T5 |
| 32 |  Ashton JeantyRB10 · LV | 122 | 328 rush · 4 TD | 7 | 10.3 | 32.7 | ▼1.6 | | T5 |
| 33 |  Derrick HenryRB11 · BAL | 121 | 579 rush · 8 TD | 7 | 5 | 35.3 | ▼3.7 | | T5 |
| 35 |  Jaylen WarrenRB12 · PIT | 120 | 561 rush · 2 TD | 7 | 9.7 | 36.8 | ▲2.8 | | T5 |
| 37 |  James Cook IIIRB13 · BUF | 114 | 627 rush · 6 TD | 6 | 9.9 | 24.3 | ▲1.8 | | T6 |
| 41 |  Bucky IrvingRB14 · TB | 110 | 558 rush · 5 TD | 7 | 6.1 | 31.5 | ▼0.4 | | T6 |
| 43 |  Chuba HubbardRB15 · CAR | 108 | 459 rush · 6 TD | 6 | 10 | 25.9 | ▼1.1 | | T6 |
| 63 |  Bhayshul TutenRB16 · JAX | 88 | 388 rush · 4 TD | 6 | 9.8 | 24.7 | ▲1.0 | | T6 |
| 64 |  Tony PollardRB17 · TEN | 88 | 478 rush · 4 TD | 7 | 4.4 | 36.5 | ▲2.6 | | T6 |
| 65 |  Isiah PachecoRB18 · DET | 87 | 462 rush · 2 TD | 13 | 3 | 12.8 | ▼1.3 | | T6 |
| 70 |  Rhamondre StevensonRB19 · NE | 85 | 285 rush · 3 TD | 7 | 3.6 | 22.5 | ▲1.2 | | T6 |
| 75 |  Quinshon JudkinsRB20 · CLE | 80 | 317 rush · 3 TD | 6 | 7 | 23.4 | ▲1.3 | | T6 |
| 80 |  Braelon AllenRB21 · NYJ | 76 | 418 rush · 2 TD | 7 | 4 | 19.4 | ▲1.9 | | T6 |
| 85 |  Chase BrownRB22 · CIN | 75 | 285 rush · 1 TD | 6 | 7 | 19.1 | ▼1.3 | | T6 |
| 86 |  Emanuel WilsonRB23 · SEA | 75 | 403 rush · 4 TD | 7 | 0.3 | 27 | ▲2.4 | | T6 |
| 88 |  Aaron Jones Sr.RB24 · MIN | 74 | 436 rush · 2 TD | 6 | 3.6 | 18.7 | ▲0.5 | | T6 |
| 95 |  Cam SkatteboRB25 · NYG | 70 | 418 rush · 2 TD | 7 | 0 | 19.1 | ▼0.7 | | T6 |
| 102 |  Blake CorumRB26 · LAR | 70 | 316 rush · 3 TD | 7 | 3.1 | 17.1 | ▲0.9 | | T6 |
| 107 |  RJ HarveyRB27 · DEN | 67 | 87 rush · 2 TD | 6 | 0.7 | 19.3 | ▲0.6 | | T6 |
| 112 |  Alvin KamaraRB28 · NO | 66 | 125 rush · 3 TD | 6 | 2.6 | 22.8 | ▲0.8 | | T6 |
| 114 |  Ollie Gordon IIRB29 · MIA | 65 | 339 rush · 4 TD | 6 | 0 | 18 | ▲2.2 | | T6 |
| 125 |  Woody MarksRB30 · HOU | 63 | 271 rush · 2 TD | 7 | 5 | 12.5 | ▲0.9 | | T6 |
| 138 |  Devin NealRB31 · WSH | 60 | 206 rush · 2 TD | 10 | — | — | — | — | T6 |
| 145 |  J.K. DobbinsRB32 · DEN | 58 | 293 rush · 3 TD | 7 | 3.6 | 15.4 | ▲1.9 | | T6 |
| 147 |  Omarion HamptonRB33 · LAC | 58 | 289 rush · 3 TD | 6 | 4.9 | 17.5 | ▲0.3 | | T6 |
| 159 |  Brian Robinson Jr.RB34 · ATL | 53 | 211 rush · 4 TD | 6 | 1.6 | 25.7 | ▲1.2 | | T6 |
| 167 |  Jeremiyah LoveRB35 · ARI | 51 | 245 rush · 2 TD | 5 | 2.2 | 21.9 | — | | T6 |
| 168 |  Justin JacksonRB36 · DET | 51 | 170 rush · 2 TD | 16 | 0 | 8.7 | ▲1.1 | | T6 |
| 176 |  MarShawn LloydRB37 · GB | 49 | 142 rush · 3 TD | 7 | 1 | 16.7 | ▲0.4 | | T6 |
| 181 |  Rachaad WhiteRB38 · WSH | 49 | 145 rush · 2 TD | 5 | 3 | 15.7 | — | | T6 |
| 187 |  Tyler AllgeierRB39 · ARI | 48 | 176 rush · 1 TD | 7 | 3.6 | 12.9 | ▲0.2 | | T6 |
| 193 |  David MontgomeryRB40 · HOU | 46 | 138 rush · 3 TD | 5 | 1.1 | 28.9 | — | | T6 |
| 197 |  Jacory Croskey-MerrittRB41 · WSH | 45 | 239 rush · 2 TD | 5 | 5.3 | 14.2 | — | | T6 |
| 204 |  Jerome FordRB42 · ARI | 44 | 73 rush · 0 TD | 13 | — | — | — | — | T6 |
| 206 |  Salvon AhmedRB43 · CHI | 43 | 61 rush · 2 TD | 8 | — | — | — | — | T6 |
| 210 |  Malik DavisRB44 · DAL | 41 | 250 rush · 2 TD | 10 | — | — | — | — | T6 |
| 217 |  Kenny GainwellRB45 · TB | 39 | 149 rush · 1 TD | 7 | 2.8 | 10.7 | ▲0.8 | | T6 |
| 220 |  Kendre MillerRB46 · NO | 39 | 159 rush · 2 TD | 6 | 1.9 | 9 | ▼0.5 | | T6 |
| 221 |  Saquon BarkleyRB47 · PHI | 38 | 244 rush · 1 TD | 5 | 2 | 15.1 | — | | T6 |
| 223 |  Samaje PerineRB48 · CIN | 38 | 126 rush · 2 TD | 6 | 0.7 | 15.8 | ▼0.3 | | T6 |
| 229 |  Keaton MitchellRB49 · LAC | 37 | 139 rush · 1 TD | 6 | 0.4 | 13.7 | ▲1.1 | | T6 |
| 234 |  George HolaniRB50 · SEA | 36 | 108 rush · 1 TD | 7 | 2.5 | 10.8 | ▲1.0 | | T6 |
| 235 |  Justice HillRB51 · BAL | 35 | 140 rush · 0 TD | 7 | 3.3 | 9.8 | ▲0.5 | | T6 |
| 241 |  Kimani VidalRB52 · LAC | 34 | 109 rush · 2 TD | 6 | 0 | 12.6 | ▲1.1 | | T6 |
| 244 |  TreVeyon HendersonRB53 · NE | 34 | 203 rush · 1 TD | 6 | 3 | 13.6 | ▼1.6 | | T6 |
| 249 |  Tyrone Tracy Jr.RB54 · NYG | 32 | 55 rush · 3 TD | 7 | -0.6 | 18.5 | ▲1.9 | | T6 |
| 254 |  Kaelon BlackRB55 · SF | 31 | 233 rush · 1 TD | 7 | 1.3 | 10.9 | ▼0.3 | | T6 |
| 255 |  Chris Rodriguez Jr.RB56 · JAX | 30 | 168 rush · 2 TD | 6 | 1.3 | 9.7 | ▲0.6 | | T6 |
| 259 |  Mike Washington Jr.RB57 · LV | 30 | 195 rush · 1 TD | 7 | 0.7 | 11.4 | ▲0.7 | | T6 |
| 266 |  Roschon JohnsonRB58 · CHI | 28 | 86 rush · 1 TD | 7 | 0 | 14.5 | ▲1.6 | | T6 |
| 270 |  Sincere McCormickRB59 · SF | 27 | 183 rush · 0 TD | 5 | — | — | — | — | T6 |
| 271 |  Tyjae SpearsRB60 · TEN | 27 | 66 rush · 0 TD | 6 | 0.5 | 9.8 | — | | T6 |
| 276 |  Emmett JohnsonRB61 · KC | 26 | 62 rush · 0 TD | 6 | 1.7 | 8.8 | ▼0.9 | | T6 |
| 277 |  Jaret PattersonRB62 · CLE | 26 | 159 rush · 1 TD | 6 | — | — | — | — | T6 |
| 284 |  Bam KnightRB63 · ARI | 24 | 160 rush · 0 TD | 7 | 0 | 11.8 | ▲0.9 | | T6 |
| 289 |  Raheim SandersRB64 · CLE | 23 | 43 rush · 0 TD | 5 | 2.1 | 9.1 | — | | T6 |
| 296 |  Jaydon BlueRB65 · PHI | 20 | 129 rush · 1 TD | 5 | — | — | — | — | T6 |
| 298 |  Sean TuckerRB66 · TB | 20 | 80 rush · 2 TD | 5 | 0 | 11.2 | — | | T6 |
| 300 |  Will ShipleyRB67 · PHI | 20 | 57 rush · 1 TD | 5 | 2.1 | 8.3 | — | | T6 |
| 304 |  Jaleel McLaughlinRB68 · CLE | 19 | 72 rush · 1 TD | 6 | 0 | 9.5 | ▲0.6 | | T6 |
| 306 |  Seth McGowanRB69 · IND | 19 | 134 rush · 0 TD | 7 | 0 | 5.8 | ▲0.9 | | T6 |
| 307 |  Israel AbanikandaRB70 · DAL | 18 | 70 rush · 0 TD | 6 | — | — | — | — | T6 |
| 321 |  Corey KinerRB71 · NE | 17 | 151 rush · 0 TD | 7 | 0 | 5.7 | ▲0.7 | | T6 |
| 337 |  Tyler BadieRB72 · DEN | 15 | 22 rush · 0 TD | 5 | 0.6 | 5.9 | — | | T6 |
| 339 |  Sione VakiRB73 · DET | 15 | 56 rush · 0 TD | 6 | 0.5 | 4.7 | ▼0.1 | | T6 |
| 340 |  Isaiah DavisRB74 · NYJ | 15 | 29 rush · 0 TD | 7 | 0 | 8.4 | ▲0.8 | | T6 |
| 356 |  Dylan LaubeRB75 · LV | 12 | 9 rush · 1 TD | 7 | -2 | 11.5 | ▲0.3 | | T6 |
| 362 |  Deuce VaughnRB76 · HOU | 12 | 70 rush · 0 TD | 7 | — | — | — | — | T6 |
| 365 |  CJ DonaldsonRB77 · NO | 11 | 81 rush · 0 TD | 7 | 0 | 4.3 | ▲0.4 | | T6 |
| 370 |  Kaleb JohnsonRB78 · GB | 10 | 104 rush · 0 TD | 6 | -0.2 | 3.2 | ▲0.3 | | T6 |
| 374 |  DJ GiddensRB79 · IND | 10 | 96 rush · 0 TD | 9 | — | — | — | — | T6 |
| 375 |  Tyler GoodsonRB80 · DAL | 10 | 72 rush · 0 TD | 5 | 0 | 3.8 | — | | T6 |
| 376 |  Zamir WhiteRB81 · NO | 10 | 32 rush · 0 TD | 6 | — | — | — | — | T6 |
| 381 |  DeeJay DallasRB82 · MIN | 8 | 10 rush · 0 TD | 6 | 0 | 3 | ▲0.1 | | T6 |
| 385 |  Ray DavisRB83 · BUF | 8 | 12 rush · 0 TD | 6 | 0 | 4.3 | ▲0.2 | | T6 |
| 397 |  Ameer AbdullahRB84 · JAX | 7 | 45 rush · 0 TD | 6 | 0 | 4.2 | ▼0.6 | | T6 |
| 418 |  Jordan JamesRB85 · SF | 4 | 21 rush · 0 TD | 5 | 0 | 2.7 | — | | T6 |
| 420 |  Kaytron AllenRB86 · MIA | 4 | 41 rush · 0 TD | 5 | 0 | 2.4 | — | | T6 |
| 423 |  Nate CarterRB87 · KC | 4 | 60 rush · 0 TD | 7 | — | — | — | — | T6 |
| 424 |  Velus Jones Jr.RB88 · SEA | 4 | 28 rush · 0 TD | 6 | 0 | 2.9 | ▲0.1 | | T6 |
| 427 |  Jaylen WrightRB89 · MIA | 4 | 36 rush · 0 TD | 5 | -0.1 | 1.1 | — | | T6 |
| 432 |  LeQuint Allen Jr.RB90 · JAX | 3 | 1 rush · 0 TD | 6 | 0 | 2.9 | ▲0.1 | | T6 |
| 444 |  Rasheen AliRB91 · BAL | 2 | 19 rush · 0 TD | 7 | 0 | 1.9 | ▲0.1 | | T6 |
| 445 |  Chris CollierRB92 · LV | 2 | 12 rush · 0 TD | 8 | — | — | — | — | T6 |
| 451 |  Travis HomerRB93 · PIT | 2 | 15 rush · 0 TD | 6 | -0.1 | 1.6 | ▼0.3 | | T6 |
| 453 |  Brashard SmithRB94 · KC | 1 | 0 rush · 0 TD | 5 | 0 | 1.4 | — | | T6 |
| 459 |  Lew NicholsRB95 · PIT | 1 | 6 rush · 0 TD | 5 | 0 | 0.6 | — | | T6 |
| 460 |  Tahj BrooksRB96 · CIN | 1 | 6 rush · 0 TD | 6 | 0 | 0.6 | — | | T6 |